1,2-Dichloro-3-methoxy-5-nitro-benzene synthesis
- Product Name:1,2-Dichloro-3-methoxy-5-nitro-benzene
- CAS Number:1351862-12-8
- Molecular formula:C7H5Cl2NO3
- Molecular Weight:222.03
41956-18-7
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1351862-12-8
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Yield:1351862-12-8 94%
Reaction Conditions:
Stage #1: 2-chloro-6-methoxy-4-nitroanilinewith hydrogenchloride in water at 0;
Stage #2: with sodium nitrite in water at 20;
Stage #3: with hydrogenchloride;copper(l) chloride in water at 60 - 80;
References:
Bollini, Mariela;Domaoal, Robert A.;Thakur, Vinay V.;Gallardo-Macias, Ricardo;Spasov, Krasimir A.;Anderson, Karen S.;Jorgensen, William L. [Journal of Medicinal Chemistry,2011,vol. 54,# 24,p. 8582 - 8591] Location in patent:supporting information; experimental part