1,2-Dimethyl-1H-pyrrole-3-carboxylic acid synthesis
- Product Name:1,2-Dimethyl-1H-pyrrole-3-carboxylic acid
- CAS Number:89776-57-8
- Molecular formula:C7H9NO2
- Molecular Weight:139.15
19406-11-2
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89776-57-8
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Yield:-
Reaction Conditions:
with water;lithium hydroxide in 1,4-dioxane at 100; for 16 h;
Steps:
4b.B Step B: 1,2-Dimethyl-JH-pyrrole-3-carboxylic acid
Step B: 1,2-Dimethyl-JH-pyrrole-3-carboxylic acid To a solution of the product from Step A (5.3 g, 31.7 mmol) in 1 ,4-dioxane (60 mL) is added lM LiOH (2.66 g, 63.4 minol) in water (60 ml) and the reaction stirred at 100 °C for cci 16 h. The reaction is allowed to cool to ambient temperature, diluted with water and acidified with 2M Rd. The resulting precipitate is collected by vacuum filtration to affordthe desired product. The filtrate is extracted with ethyl acetate and the organic extracts dried over magnesium sulphate, filtered and concentrated to obtain an additional crop of desired product.LC/1VLS (C7H9N02) no ionisation; RT 0.71 (Method B)
References:
WO2015/11164,2015,A1 Location in patent:Page/Page column 53; 54
936-12-9
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89776-57-8
42 suppliers
$40.00/100mg