1,2-Dimethyl-4-phenyl-1H-pyrrole synthesis
- Product Name:1,2-Dimethyl-4-phenyl-1H-pyrrole
- CAS Number:52266-24-7
- Molecular formula:C12H13N
- Molecular Weight:171.24
1192717-69-3
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Yield:52266-24-7 91%
Reaction Conditions:
with 2-aminoethan-1-ol at 175; for 1 h;Inert atmosphere;
Steps:
1.5 The fifth step: preparation of 1,2-dimethyl-4-phenyl-1H-pyrrole (A-6)
Compound A-5 (4.8 g, 18.5 mmol) and ethanolamine (13 mL) were added to the reaction flask, the reaction solution was replaced with nitrogen, and the reaction was carried out at 175° C. for 1 h. LC-MS showed that the reaction was complete.Water was added to the reaction system, extracted twice with ethyl acetate, the organic phases were combined, washed with saturated brine, and dried over anhydrous Na2SO4. After vacuum evaporation, the crude product was purified by silica gel column to obtain 2.9 g of white solid product A-6. Rate: 91%.
References:
WO2022/134837,2022,A1 Location in patent:Page/Page column 27; 29
94-02-0
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3651-13-6
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161560-98-1
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