1-(2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL)ETHANOL synthesis

Yield:-

Reaction Conditions:

Stage #1: methylmagnesium bromide;2-fluoro-5-trifluoromethylbenzaldehyde in tetrahydrofuran at 0 - 20; for 0.5 h;
Stage #2: with ammonium chloride in tetrahydrofuran;water;

Steps:

29.1

3.0 M methylmagnesiumbromide (7.8 ml) was dropped, in a nitrogen atmosphere at 0 °C, into the THF (30 ml) solution of 2-fluoro-5-trifluoromethyl benzaldehyde (3.0 g). After the mixture was warmed to room temperature, and was then stirred for 30 minutes, it was poured into a saturated ammonium chloride aqueous solution, and was then subjected to extraction with ethyl acetate. After its organic layer was washed with brine, and was then dried with anhydrous magnesium sulfate, it was filtered, and was then concentrated under reduced pressure to produce a crude chemical compound (58) (3.42 g).

References:

EP1731518,2006,A1 Location in patent:Page/Page column 41