1-(2-Hydroxyethyl)-3,7-dimethylxanthine synthesis

6synthesis methods

Product Name:1-(2-Hydroxyethyl)-3,7-dimethylxanthine
CAS Number:1507-14-8
Molecular formula:C9H12N4O3
Molecular Weight:224.22

624-76-0 Synthesis

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Yield:1507-14-8 94%

Reaction Conditions:

with sodium hydride in N,N-dimethyl-formamide; for 4 h;

Steps:

8; 9; 10 Synthesis of Compound 8: 1-(acetic acid-2-ethyl ester)-3,7-dimethylxanthine

taking theobromine 540mg (3mmoL), NaH 720mg (30mmol) dissolved in 80mL DMF, adding 2mmol of 2-iodoethanol under the drop, after 4 hours of reaction, quenching the reaction with water, spin dry, oil Ether: CH3CH2OCOCH3 = 3:1 (v/v) as a mobile phase over silica gel to give compound 1-ethylhydroxy-3-7-dimethylxanthine, yield 94%.

References:

CN109912598,2019,A Location in patent:Paragraph 0054-0055; 0058-0059; 0062-0063