1(2H)-Isoquinolinone, 4-bromo-7-methyl- synthesis

Yield:-

Reaction Conditions:

with bromine;acetic acid at 20; for 4 h;

Steps:

41.B

Step B: A solution of bromine (4.8 ml, 94 mmol) in acetic acid (50 ml) was added dropwise to a solution of the product from Step A (15.0 g, 94 mmol) in acetic acid (300 ml) at room temperature. The mixture was stirred at room temperature for 4 hours, poured into iced water, extracted with dichloromethane three times and dried over magnesium sulfate to give the desired product (24.2 g): ¹H NMR (300 MHz, CDCl₃) δ 8.24 (s, 1H), 7.80 (d, J=8.4 Hz, 1H), 7.63 (dd, J=8.4, 1.8 Hz, 1H), 7.39 (s, 1H), 2.55 (s, 3H).

References:

US2006/52378,2006,A1 Location in patent:Page/Page column 104