1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine synthesis
- Product Name:1-(3,4-dichlorobenzyl)-1H-pyrazol-3-amine
- CAS Number:895929-56-3
- Molecular formula:C10H9Cl2N3
- Molecular Weight:242.1
1003011-48-0
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Yield:-
Reaction Conditions:
with hydrazine;nickel in tetrahydrofuran; for 0.0833333 h;
Steps:
29
To a solution containing 1-(3,4-dichloro-benzyl)-3-nitro-1H-pyrazole (115 mg, 0.42 mmol) in tetrahydrofuran (2 mL), anhydrous hydrazine (100 μL) was added to the clear solution. Raney nickel (100 mg washed 3 times with 5 mL of anhydrous tetrahydrofuran) was then added in tetrahydrofuran (300 μL). Gas evolved from the mixture and the reaction was allowed to proceed for 5 min, after which time the raney nickel was removed by filtration through a celite plug. The solvent was removed in vacuo to afford 1-(3,4-dichloro-benzyl)-1H-pyrazol-3-ylamine as a yellow oil which was used in the following step with no further purification.
References:
US2008/21032,2008,A1 Location in patent:Page/Page column 39
18880-04-1
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895929-56-3
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