1-(3',4'-DIMETHYLPHENYL)ETHYLAMINE synthesis

Yield:91251-29-5 51%

Reaction Conditions:

in ammonium formate;

Steps:

P.3 Preparation of Benzylamine Derivative

PREPARATION EXAMPLE 3 Preparation of Benzylamine Derivative Commercially available 3,4-dimethylacetophenone in the amount of 26.1 grams (176 millimoles) was mixed with 35.4 grams (562 millimoles) of ammonium formate, and the resulting mixture was stirred at 180° C. for 5 hours. Thereafter the same procedure as in preparative example 1 was performed to yield a free oil layer. This oil layer was separated and subjected to vacuum distillation under conditions of 68.5° C. and 0.35 mmHg to yield 13.4 grams (89.8 millimoles) of a benzylamine derivative, 3,4-dimethyl-α-methylbenzylamine (yield, 51%).

References:

US4680054,1987,A