1-(3-aMino-4-(benzyloxy)-2-hydroxyphenyl)ethanone synthesis
- Product Name:1-(3-aMino-4-(benzyloxy)-2-hydroxyphenyl)ethanone
- CAS Number:871101-87-0
- Molecular formula:C15H15NO3
- Molecular Weight:257.28
1035229-31-2
871101-87-0
The general procedure for the synthesis of 1-(3-amino-4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone from 1-(4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone was carried out as follows: zinc powder (5.50 g, 84.1 mmol) was added batchwise to 1-(4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone (5.50 g, 19.2 mmol) in a suspension in acetic acid (55 mL), and the reaction was carried out with an ice bath to control the internal temperature not to exceed 40 °C for 15 min. The reaction mixture was then warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filter cake was washed with acetic acid. The filtrate was slowly poured into an ice-water mixture (500 mL) and a solid was precipitated. The precipitate was collected by filtration, washed with water and dried under vacuum at 40 °C to afford the target product 1-(3-amino-4-(benzyloxy)-2-hydroxyphenyl)ethanone (4.80 g, 18.7 mmol, 97% yield) as a light brown solid. The mass spectrum (ESI+) showed the molecular ion peak m/z 258 [M + H]+.
1035229-31-2
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$130.00/100mg
871101-87-0
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$327.00/1g
Yield:871101-87-0 97%
Reaction Conditions:
with acetic acid;zinc at 40; for 2.25 h;Inert atmosphere;
References:
Sweis, Ramzi F.;Wang, Zhi;Algire, Mikkel;Arrowsmith, Cheryl H.;Brown, Peter J.;Chiang, Gary G.;Guo, Jun;Jakob, Clarissa G.;Kennedy, Steven;Li, Fengling;Maag, David;Shaw, Bailin;Soni, Nirupama B.;Vedadi, Masoud;Pappano, William N. [ACS Medicinal Chemistry Letters,2015,vol. 6,# 6,p. 695 - 700] Location in patent:supporting information
601-89-8
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871101-87-0
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$327.00/1g
89684-58-2
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$209.03/1g
871101-87-0
25 suppliers
$327.00/1g