Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1-(3-bromophenyl)-2-methylpropan-2-amine
808769-14-4

1-(3-bromophenyl)-2-methylpropan-2-amine synthesis

4synthesis methods
Acetamide, N-[2-(3-bromophenyl)-1,1-dimethylethyl]-2-chloro-

808769-15-5
0 suppliers
inquiry

1-(3-bromophenyl)-2-methylpropan-2-amine

808769-14-4
11 suppliers
inquiry

-

Yield:808769-14-4 96%

Reaction Conditions:

with acetic acid;thiourea in ethanol;Heating / reflux;

Steps:

37

A solution of the product of preparation 36 (32.0 g, 105 mmol), thiourea (9.60 g, 126 mmol) and acetic acid (50 mL) in ethanol (250 mL) was heated to reflux overnight. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated in vacuo, basified using aqueous sodium hydroxide solution (1M, 450 mL) and extracted with dichloromethane (2x 500 mL). The combined organic solution was washed with brine (50 mL), dried over sodium sulfate and concentrated in vacuo to afford the title compound as a black oil in 96% yield, 23 g. 'H NMR (400MHz, CDCl3) 8 : 1.12 (6H, s), 1.84 (2H, bs), 2.62 (2H, s), 7.16-7. 08 (2H, m), 7.36-7. 32 (2H, m); LRMS ESI m/z 228 [M+H] +

References:

WO2005/92840,2005,A1 Location in patent:Page/Page column 67