1-(3-bromophenyl)-2-methylpropan-2-amine synthesis
- Product Name:1-(3-bromophenyl)-2-methylpropan-2-amine
- CAS Number:808769-14-4
- Molecular formula:C10H14BrN
- Molecular Weight:228.13
![Acetamide, N-[2-(3-bromophenyl)-1,1-dimethylethyl]-2-chloro-](/CAS/20210305/GIF/808769-15-5.gif)
808769-15-5
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Yield:808769-14-4 96%
Reaction Conditions:
with acetic acid;thiourea in ethanol;Heating / reflux;
Steps:
37
A solution of the product of preparation 36 (32.0 g, 105 mmol), thiourea (9.60 g, 126 mmol) and acetic acid (50 mL) in ethanol (250 mL) was heated to reflux overnight. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated in vacuo, basified using aqueous sodium hydroxide solution (1M, 450 mL) and extracted with dichloromethane (2x 500 mL). The combined organic solution was washed with brine (50 mL), dried over sodium sulfate and concentrated in vacuo to afford the title compound as a black oil in 96% yield, 23 g. 'H NMR (400MHz, CDCl3) 8 : 1.12 (6H, s), 1.84 (2H, bs), 2.62 (2H, s), 7.16-7. 08 (2H, m), 7.36-7. 32 (2H, m); LRMS ESI m/z 228 [M+H] +
References:
WO2005/92840,2005,A1 Location in patent:Page/Page column 67
64781-38-0
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