1-(3-CHLOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE synthesis

Yield:90815-01-3 79%

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide;Reflux;

Steps:

General Procedure for the Preparation of 3a-3i.

General procedure: Indole-3-carboxaldehyde (1, 5 mmol) was dissolved in appropriate quantity of dimethylformamide (DMF) and 2.4 ml of 1,8-Diazabicycloundec-7-ene was added. Further, 6 mmol appropriate benzyl chloride (2) was added slowly to the mixture and refluxed for >20 hours [21]. The product was extracted by fractionation from ethyl acetate and water. The organic layer was concentrated to give crude product which was then purified using column chromatography (petroleum ether: ethyl acetate).

References:

Chadha, Navriti;Silakari, Om [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 11,p. 2324 - 2330] Location in patent:supporting information