1-(4-(4-broMophenoxy)butyl)-4-Methylpiperazine synthesis
- Product Name:1-(4-(4-broMophenoxy)butyl)-4-Methylpiperazine
- CAS Number:93699-37-7
- Molecular formula:C14H21BrN2O
- Molecular Weight:313.23
Yield:93699-37-7 75%
Reaction Conditions:
with caesium carbonate in acetonitrile at 75; for 5 h;
Steps:
53.1 1-(3-(4-bromophenoxy)propyl)-4-methylpiperazine
To a mixture of 1-bromo-4-(3-bromopropoxy)benzene (300 mg, 1.02 mmol) and 1-methylpiperazine (100 mg, 1.02 mmol) in CH3CN (6 mL) was added Cs2CO3 (365 mg, 1.10 mmol).
The mixture was stirred at 75° C. for 5 hours.
The mixture was poured into ethyl acetate and washed with water.
The organic phase was dried over sodium sulfate, filtered, and concentrated to give the title compound (280 mg, 75% yield) as a yellow oil.
1H NMR (400 MHz, DMSO-d6): δ 7.32 (d, 2H), 6.80 (d, 2H), 3.88 (m, 2H), 2.51-2.09 (m, 10H), 2.05 (s, 3H), 1.75 (m, 2H).
References:
US2013/267493,2013,A1 Location in patent:Paragraph 0954; 0955
