1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanone synthesis
- Product Name:1-(4-broMo-2-fluorophenyl)-2,2,2-trifluoroethanone
- CAS Number:617706-18-0
- Molecular formula:C8H3BrF4O
- Molecular Weight:271.01
1033805-88-7
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617706-18-0
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Yield:617706-18-0 95%
Reaction Conditions:
with 2-iodoxybenzoic acid in ethyl acetate;Reflux;
Steps:
32.2
To a solution of 1-(4-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol (1.09 g, 3.99 mmol) in ethyl acetate (30 mL) was added 2-iodoxybenzoic acid (2.28 g, 7.97 mmol). The reaction was heated to reflux overnight. The reaction was cooled to room temperature and diluted with heptanes (30 mL). The mixture was filtered through Celite and the filtrate was concentrated to give the title compound (1.03 g, 95%) as a pale yellow oil. 1H NMR (400 MHz, CDCl3, δ): 7.44 (dd, J=10.15, 1.56 Hz, 1H), 7.48 (m, 1H), 7.76 (m, 1H).
References:
US2012/108619,2012,A1 Location in patent:Page/Page column 42
57848-46-1
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617706-18-0
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$120.00/250mg
1073-06-9
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617706-18-0
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632324-41-5
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617706-18-0
34 suppliers
$120.00/250mg