1-(4-bromophenyl)-5-methyl-1,2,3-triazole synthesis
- Product Name:1-(4-bromophenyl)-5-methyl-1,2,3-triazole
- CAS Number:20177-64-4
- Molecular formula:C9H8BrN3
- Molecular Weight:238.08
4202-14-6
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Yield:20177-64-4 91%
Reaction Conditions:
with N,N,N',N'-tetramethylguanidine in acetonitrile at 80; for 16 h;
Steps:
2 Example 2
In a round bottom flask, 4-bromophenyl azide (0.1 mmol)Tetramethylguanidine (0.3 mmol) was further added,Stir wellThen further dimethyl acetonylphosphonate (0.1 mmol) was added,After stirring at 80 for 16h,The entire reaction was monitored by TLC until the reaction was completed.Finally, the crude product is extracted with water and ethyl acetate,Dried over anhydrous magnesium sulfate,Then separated by silica gel column to obtain pure product,The yield is 91%
References:
CN105949136,2016,A Location in patent:Paragraph 0008; 0012
20725-34-2
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