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126278-69-1

1-(4-Ethoxy-3-methoxyphenyl)propan-2-one synthesis

2synthesis methods
-

Yield:126278-69-1 79%

Reaction Conditions:

Stage #1: 2-chloro-propionic acid methyl ester;4-ethoxy-3-methoxybenzaldehydewith sodium methylate in methanol;toluene at 0 - 20; for 24 h;
Stage #2: with sodium hydroxide in toluene at 50;
Stage #3: with hydrogenchloride;water in toluene at 80 - 85; for 2 h;

References:

Lakó, ágnes;Mendon?a, Ricardo;Molnár, Zsófia;Poppe, László [RSC Advances,2020,vol. 10,# 67,p. 40894 - 40903]