1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE synthesis
- Product Name:1-(5-CHLORO-2-NITROPHENYL)-1-ETHANONE
- CAS Number:18640-60-3
- Molecular formula:C8H6ClNO3
- Molecular Weight:199.59
99-02-5
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Yield: 85%
Reaction Conditions:
with sulfuric acid;nitric acid at -18;
Steps:
2.1 Synthesis of 2-nitro-5-chloroacetophenone
100 g of m-chloroacetophenone was slowly added dropwise to 500 ml of sulfuric acid nitric acid mixture (volume ratio 1: 6.5, minus 18 degrees), and the temperature was stirred overnight. Was added to ice water and filtered to give 110 g of 2-nitro-5-chloroacetophenone as a yellow solid in 85% yield.
References:
shanghai Bide pharmatech co. ltd;Wang, Chao;Li, Ronghao;Huang, Dongrui;Liu, Han CN102898374, 2016, B Location in patent:Paragraph 0035-0038
16994-13-1
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