1-(5-Methoxy-6-nitroindolin-1-yl)ethanone synthesis

Yield:23772-37-4 65%

Reaction Conditions:

with nitric acid;acetic anhydrideregioselective reaction;

References:

Chamberlain, Stanley D.;Redman, Aniko M.;Wilson, Joseph W.;Deanda, Felix;Shotwell, J. Brad;Gerding, Roseanne;Lei, Huangshu;Yang, Bin;Stevens, Kirk L.;Hassell, Anne M.;Shewchuk, Lisa M.;Leesnitzer, M. Anthony;Smith, Jeffery L.;Sabbatini, Peter;Atkins, Charity;Groy, Arthur;Rowand, Jason L.;Kumar, Rakesh;Mook Jr., Robert A.;Moorthy, Ganesh;Patnaik, Samarjit [Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,# 2,p. 360 - 364] Location in patent:scheme or table