1-(6-hydroxyindolin-1-yl)ethanone synthesis
- Product Name:1-(6-hydroxyindolin-1-yl)ethanone
- CAS Number:4770-34-7
- Molecular formula:C10H11NO2
- Molecular Weight:177.2
Yield:4770-34-7 89%
Reaction Conditions:
in water at 20;Sonication;Heating;
Steps:
l-(6-hydroxyindolin-l-yl)ethan-l-one (96)
Compound 90 (0.8 g, 5.92 mmol) was suspended in 10 mL DI water, to which Acetic anhydride (2.24 mL, 23.67 mmol) was added dropwise. The reaction mixture was placed in an (0886) ultrasonication bath for 1 min, then was stirred in a water bath (50° C) for 10 min. The resulting solution was stirred overnight at rt. After which, the solid was collected via vacuum filtration and washed with small portions of DI water. The product was left in the funnel and air dried overnight to afford compound 96 (929 mg, 89%) as a light gray solid, which was used for the next step without further purification.
References:
WO2020/23911,2020,A2 Location in patent:Page/Page column 104
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