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435277-99-9

1-(9,9-Dimethylfluuoren-2-yl)isoquinoline synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-BuLi; B(OCH3)3 / hexane; tetrahydrofuran / -70 °C
1.2: 14 percent / acidic aq. solution
2.1: 54 percent / Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / Heating

References:

Tsuboyama, Akira;Iwawaki, Hironobu;Furugori, Manabu;Mukaide, Taihei;Kamatani, Jun;Igawa, Satoshi;Moriyama, Takashi;Miura, Seishi;Takiguchi, Takao;Okada, Shinjiro;Hoshino, Mikio;Ueno, Kazunori [Journal of the American Chemical Society,2003,vol. 125,# 42,p. 12971 - 12979]