1-Acetyl-piperidine-2-carboxylic acid Methyl ester synthesis
- Product Name:1-Acetyl-piperidine-2-carboxylic acid Methyl ester
- CAS Number:111479-14-2
- Molecular formula:C9H15NO3
- Molecular Weight:185.2203
Yield:111479-14-2 50%
Reaction Conditions:
in methanol;dichloromethane;
Steps:
2 EXAMPLE 2
EXAMPLE 2 (S)-pipecolic acid (1.0 g, 7.7 mmol) was treated with trimethyl orthoacetate (15 ml, 171 mmol, 22 eq. 15 vol) and methanol (5 ml, 5 vol). The mixture was stirred and heated for 48 h and then concentrated in vacuo. The residue was dissolved in dichloromethane (10 ml) and filtered through a silica gel plug to yield N-acetylpipecolic acid, methyl ester (730 mg, 50%) which was racemic by GC analysis and had a 1 H nmr spectrum which compared favourably with authentic material.
References:
US6156900,2000,A
108-24-7
5 suppliers
$14.00/250ML
32559-18-5
93 suppliers
$23.00/25g
111479-14-2
3 suppliers
inquiry
4043-87-2
251 suppliers
inquiry
111479-14-2
3 suppliers
inquiry