1-Aminomethyl-cyclohexylamine dihydrochloride synthesis
- Product Name:1-Aminomethyl-cyclohexylamine dihydrochloride
- CAS Number:123194-05-8
- Molecular formula:C7H18Cl2N2
- Molecular Weight:201.1372
5496-10-6
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123194-05-8
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$90.00/50mg
Yield:123194-05-8 89%
Reaction Conditions:
with hydrogenchloride;hydrogen;platinum(IV) oxide in ethanol; under 2585.81 Torr; for 20 h;
Steps:
54.B
A mixture of l-aminocyclohexanecarbonitrile (48.5 g, 391 mmol) and platinum oxide (5.0 g) in 4.2 M HCl in ethanol (200 mL) and 2.7 M HCl in ethanol (300 mL) was hydrogenated at 50 psi (3.4 x 105 Pa) for 20 h on a Parr apparatus. The reaction mixture was filtered through CELITE filter agent and the filtrate was concentrated to yield a clear oil. The oil was triturated with isopropanol to yield a white solid that was isolated by filtration, washed with ether, and dried to provide l-(aminomethyl)cyclohexanamine dihydrochloride (70.0 g, 89%).
References:
WO2006/28545,2006,A2 Location in patent:Page/Page column 119
143-33-9
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108-94-1
568 suppliers
$12.00/50g
123194-05-8
18 suppliers
$90.00/50mg
108-94-1
568 suppliers
$12.00/50g
123194-05-8
18 suppliers
$90.00/50mg