1-(aminooxy)-2-methylpropan-2-ol synthesis
- Product Name:1-(aminooxy)-2-methylpropan-2-ol
- CAS Number:90792-83-9
- Molecular formula:C4H11NO2
- Molecular Weight:105.14
1009334-87-5
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Yield:90792-83-9 100%
Reaction Conditions:
with methylhydrazine in dichloromethane at 0; for 2 h;
Steps:
2
To a solution of 2-(2-Hydroxy-2-methyl-propoxy)-isoindole-l,3-dione (3,70 g,15.7 mmol) in anhydrous dichloromethane (25 mL) under nitrogen at 00C was added methyl hydrazine (0.879 mL, 16.50 mmol) and stirred for 2 hours at 00C. The addition of methyl hydrazine resulted in a pale yellow color followed by a white precipitate. The reaction was filtered after 2 hours at 00C and the solid was discarded. The filtrate was concentrated under reduced pressure to give the title compound as a pale yellow oil (1.65 g, 100%). LCMS (method C): Rx = 0.34 min, M+H+ = 106.1. IH NMR (DMSO-d6, 400MHz) 3.60 (s, 2H), 1.22 (s , 6H).
References:
WO2008/24725,2008,A1 Location in patent:Page/Page column 114
89855-31-2
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