1-Azido-4-ethyl-benzene synthesis
- Product Name:1-Azido-4-ethyl-benzene
- CAS Number:128654-33-1
- Molecular formula:C8H9N3
- Molecular Weight:147.18
589-16-2
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Yield:128654-33-1 64%
Reaction Conditions:
Stage #1: 4-aminoethylbenzenewith hydrogenchloride;sodium nitrite in water at 20; for 1 h;
Stage #2: with sodium azide in water at 20;
Steps:
17 Example 17: Preparation of derivatives (7-14) shown by compounds of general formula 7
Dissolve 4-ethylaniline in an aqueous hydrochloric acid solution with a mass percentage of 10% at room temperature, stir evenly, add dropwise an aqueous solution of sodium nitrite, react for one hour, and then add dropwise an aqueous solution of sodium azide, stir at room temperature for 1-2 Hour. Sodium bicarbonate was slowly added to the system to make the system weakly basic, extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate, and evaporated to dryness to obtain a brown oily liquid, yield: 64%.
References:
CN113999211,2022,A Location in patent:Paragraph 0050; 0108-0109
25309-64-2
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63139-21-9
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