1-BENZOFURAN-6-OL synthesis
- Product Name:1-BENZOFURAN-6-OL
- CAS Number:13196-11-7
- Molecular formula:C8H6O2
- Molecular Weight:134.13
50551-63-8
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$62.00/100mg
13196-11-7
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$185.00/250mg
Yield: 90%
Reaction Conditions:
with sodium dodecanethiolate in N,N-dimethyl-formamide at 130; for 3 h;Large scale;Temperature;Reagent/catalyst;
Steps:
6-Hydroxybenzofuran (1)
DMF (18 L), sodium dodecanethiolate (7.6 kg, 33.9 mol), and 4 (2.95 kg, 19.9 mol)were added to a 50-L reactor. The reaction mixture was heated and stirred at 130 Cfor 3 h, then cooled to rt, and 4 N NaOH was added to adjust the pH to 13. Thesolution was extracted with petroleum ether three times. The aqueous phase was acidified with 2 N HCl to pH 2 and extracted with ethyl acetate three times. Theethyl acetate phases were combined, washed with water, and dried over sodiumsulfate. The solvent was removed under vacuum and the residue was left overnightat room temperature to afford 1 as a light brown solid (2.65 kg, 90 % yield, 99.5 %purity), m.p. 54-56 C. 1H-NMR (CDCl3, ppm): d 7.55 (s, 1H), 7.44-7.46 (d, 1H),7.03 (s, 1H), 6.81-6.83 (d, 1H), 6.72 (s, 1H), 5.09 (br, 1H).
References:
Song, Shu-Yong;Lu, He-Lin;Wang, Gui-Fei;Yang, Yi-Qiu;Huang, Yun-Sheng [Research on Chemical Intermediates,2016,vol. 42,# 5,p. 4433 - 4442]
299912-77-9
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13196-11-7
113 suppliers
$185.00/250mg
![6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one](/CAS/GIF/6272-26-0.gif)
6272-26-0
203 suppliers
$9.00/1g
60-29-7
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$30.00/50g
13196-11-7
113 suppliers
$185.00/250mg
6272-26-0
203 suppliers
$9.00/1g
13196-11-7
113 suppliers
$185.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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13196-11-7
113 suppliers
$185.00/250mg