1-Benzyl-4-Methylpiperidin-3-aMine synthesis
- Product Name:1-Benzyl-4-Methylpiperidin-3-aMine
- CAS Number:1039738-27-6
- Molecular formula:C13H20N2
- Molecular Weight:204.31
1206875-41-3
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Yield:1039738-27-6 66%
Reaction Conditions:
with hydrogen bromide in acetic acid at 20; for 72 h;
Steps:
3.1
To methyl l-benzyl-4-methylpiperidin-3-ylcarbamate (4Od) was added HBr in acetic acid (5 ml, 33% HBr) and stirred at room temperature for 3 days. The reaction mixture was concentrated in vacuum to dryness to furnish l-benzyl-4-methylpiperidin-3 -amine (4Oh) (1.1 g, 66 %) as a orange solid. 1U NMR (300 MHz, DMSO) δ 10.27 (bs, IH), 8.23 (bs, 3H), 7.62 (m, 2H), 7.53 - 7.40 (m, 3H), 4.54 (s, 2H), 3.71 (m, IH), 3.61 (m, 2H), 3.16 (m, 2H), 2.34 (m, IH), 2.09 (m, IH), 1.75 (m, J= 14.3, IH), 1.05 (d, J= 7.0, 3H); MS (ES+) 205.2 (M+l).
References:
WO2011/14817,2011,A1 Location in patent:Page/Page column 94
3430-27-1
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52090-68-3
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100-39-0
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