1-benzyl-6-oxo-piperidine-3-carboxylic acid synthesis
- Product Name:1-benzyl-6-oxo-piperidine-3-carboxylic acid
- CAS Number:32749-55-6
- Molecular formula:C13H15NO3
- Molecular Weight:233.26
4332-79-0
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$45.00/25mg
32749-55-6
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Yield:32749-55-6 99%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; under 18751.9 Torr; for 20 h;Reagent/catalyst;
Steps:
11 3.1.7 General procedure B-alkene hydrogenation in a hydrogenator
General procedure: The alkene (1mmol) and catalyst (at the specified catalytic loading) were added to a small glass hydrogenation vial. A suba seal was attached and the contents were flushed with nitrogen for 10min before the dry solvent (as specified) was added. The suba seal was removed and the vial was quickly placed into the hydrogenation apparatus. The hydrogenator was filled with hydrogen to the appropriate pressure before the pressure was nearly completely released. The hydrogenator was then filled again with hydrogen and the pressure was released. This fill release cycle carried out for a total of three times to ensure the vessel was sufficiently charged with hydrogen at the stated pressure. A magnetic stirrer box was placed under the hydrogenator to enable stirring for the specified time before the hydrogen was carefully released and the apparatus was disassembled. Following concentration under reduced pressure, the product was obtained, following purified by column chromatography (where applicable).
References:
Bisset, Alexander A.;Dishington, Allan;Jones, Teyrnon;Clarkson, Guy J.;Wills, Martin [Tetrahedron,2014,vol. 70,# 40,p. 7207 - 7220]
156779-11-2
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$210.00/500mg
32749-55-6
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14376-92-2
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32749-55-6
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156779-10-1
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$60.00/100mg
32749-55-6
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5621-43-2
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32749-55-6
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