1-bromo-2-[(2-fluorophenoxy)methyl]benzene synthesis

Yield:475039-98-6 82%

Reaction Conditions:

with potassium carbonate in acetone at 50;

Steps:

4.5. General procedure for the preparation of the haloethers(6)

General procedure: The haloethers were prepared following the procedure describedby Fagnou et al.36 To a mixture of potassium carbonate (5 mmol, 690 mg) and the appropriate phenol (5 mmol), was added acetone (5 mL). To the stirring mixture was added the required benzyl bromide (2.5 mmol) followed by heating to 50 C overnight. The reaction mixture was then cooled to room temperature, poured into a solution of NaOH (2M), and extracted three times with ether. The organic extracts were dried over MgSO4 and concentrated under reduced pressure. Purification was done by column chromatography using hexane/ethyl acetate (9:1) mixtures to afford the haloethers

References:

Cano, Rafael;Pérez, Juana M.;Ramón, Diego J.;McGlacken, Gerard P. [Tetrahedron,2016,vol. 72,# 8,p. 1043 - 1050]