1-Bromo-2-ethoxy-4-fluorobenzene synthesis
- Product Name:1-Bromo-2-ethoxy-4-fluorobenzene
- CAS Number:871717-61-2
- Molecular formula:C8H8BrFO
- Molecular Weight:219.05
Yield:871717-61-2 99.6%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 24 h;
Steps:
1.1.1 intermediate compound A2 synthesis process
2-Bromo-4-fluorophenol (compound Al)25.8 g) was dissolved in DMF (100 ml)K2CO3 (20.5 g) and iodoethane (23.2 g) were added to the above solution. After the reaction solution was stirred at room temperature for 24 h,Point plate to confirm the reaction end. After stopping the reaction, after adding 400 ml of distilled water,The reaction was extracted three times with n-hexane and the organic phases were combined. The organic phase was washed three times with saturated sodium chloride,Dry, spin dry,Flash silica gel column to obtain 29.4g of 2-bromo-4-fluorophenethyl ether,As a colorless liquid, the yield was 99.6%
References:
CN104211615,2017,B Location in patent:Paragraph 0065-0068
75-03-6
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