1-bromo-3-(2-methoxyethoxy)benzene synthesis
- Product Name:1-bromo-3-(2-methoxyethoxy)benzene
- CAS Number:227305-66-0
- Molecular formula:C9H11BrO2
- Molecular Weight:231.09
591-20-8
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6482-24-2
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227305-66-0
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$367.00/5g
Yield:227305-66-0 80.7%
Reaction Conditions:
with Cs2CO3;potassium iodide in N,N-dimethyl-formamide at 70; for 12 h;
Steps:
47.1 Step 1) 1-bromo-3- (2-methoxyethoxy) benzene[1488]
A mixture of cesium carbonate (4.51 g, 14.45 mmol) , potassium iodide (560 mg, 2.89 mmol) , 3-bromophenol (1.01 g, 7.73 mmol) and 1-bromo-2-methoxyethane (1.21 g, 8.67 mmol) in DMF (20 mL) was stirred at 70 for 12 h and diluted with water (50 mL) , and then extracted with EtOAc (50 mL × 3) . The combined organic layers were concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE/EtOAc (v/v) 5/1 to give a white solid product (1.08 g, 80.7) .[1489]MS (ESI, pos. ion) m/z: 231.1 [M+1]+
References:
WO2016/615,2016,A1 Location in patent:Paragraph 00651
627-42-9
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$6.00/5g
591-20-8
358 suppliers
$10.00/1g
4296-15-5
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$27.00/100mg
227305-66-0
16 suppliers
$367.00/5g