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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 1-bromo-4-(4-bromophenyl)naphthalene
952604-26-1

1-bromo-4-(4-bromophenyl)naphthalene synthesis

2synthesis methods
1,4-dibromonaphthalene

83-53-4
345 suppliers
$10.00/1g

4-Bromophenylboronic acid

5467-74-3
468 suppliers
$8.00/1g

1-bromo-4-(4-bromophenyl)naphthalene

952604-26-1
30 suppliers
$75.00/100mg

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Yield:952604-26-1 75%

Reaction Conditions:

with potassium carbonate;tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran;water; for 24 h;Heating / reflux;Suzuki Coupling;

Steps:

26.26-A

Example 26 : Preparation of compound 85; [273][274] 26-A. Preparation of compound 26a[275] Under N atmosphere, 1,4-dibromonaphthalene (5 g, 17.5 mmol),4-bromophenylboronic acid (3.5 g, 17.5 mmol), and Pd(PPh ) (1.0 g, 0.88 mmol) were3 4 added to a 2 M aqueous solution of potassium carbonate (10 rnL) and THF (200 rnL). The mixture was refluxed under stirring for about 24 hours. After completing the reaction, the mixture was cooled to normal temperature. The organic layer was separated from the reaction mixture, dried over magnesium sulfate, and distilled under reduced pressure. The residue was purified by column chromatography to prepare compound 26a (4.8 g, 75%). MS [M] = 362

References:

WO2007/86695,2007,A1 Location in patent:Page/Page column 80-81

1-Bromo-4-iodonaphthalene

63279-58-3
152 suppliers
$18.10/250mg

4-Bromophenylboronic acid

5467-74-3
468 suppliers
$8.00/1g

1-bromo-4-(4-bromophenyl)naphthalene

952604-26-1
30 suppliers
$75.00/100mg

References