1-Bromo-4-iodo-2-nitrobenzene synthesis
- Product Name:1-Bromo-4-iodo-2-nitrobenzene
- CAS Number:713512-18-6
- Molecular formula:C6H3BrINO2
- Molecular Weight:327.9
20691-72-9
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$22.00/1g
713512-18-6
51 suppliers
$87.00/250mg
Yield: 78%
Reaction Conditions:
Stage #1:4-iodo-2-nitroaniline with sulfuric acid;sodium nitrite in water at 15;
Stage #2: with hydrogen bromide;copper(I) bromide in water at 40;
Steps:
1.2 (2) Bromine reaction on diazo
100 g of 2-nitro-4-iodoaniline was added to the reaction vessel, and a solution of 200 g of concentrated sulfuric acid and 400 mL of water was added.Stir, then add 37 g of sodium nitrite and 120 mL of water to form a solution, and control the temperature at about 15 °C.After the addition is completed, the mixture is stirred for a while to prepare a diazonium salt for use.In a separate reaction flask, 20 g of cuprous bromide and 95 g of a 40% hydrobromic acid solution were added.Stirring was carried out to control the temperature at 40 ° C, and the above diazonium salt was added dropwise.After the addition, continue to stir, keep the reaction for a period of time, let cool, add dichloroethane, stir, liquid, and steam,Obtained a brown solid, 2-bromo-5-iodonitrobenzene 97 g,The content is more than 98%, and the yield is 78%.
References:
Changzhou University;Chen Xingquan;Dong Yanmin CN109369345, 2019, A Location in patent:Paragraph 0005; 0013-0015
53324-38-2
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$7.00/1g
713512-18-6
51 suppliers
$87.00/250mg
577-19-5
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$14.00/5g
713512-18-6
51 suppliers
$87.00/250mg
88-74-4
8 suppliers
$10.00/1g
713512-18-6
51 suppliers
$87.00/250mg