1-Chloroacenaphthene synthesis

6synthesis methods

Product Name:1-Chloroacenaphthene
CAS Number:40745-49-1
Molecular formula:C12H9Cl
Molecular Weight:188.65

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Yield:-

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane at -20; for 2 h;

Steps:

1E; 8A Preparation of 1 -chloro- 1 ,2-dihydroacenaphthylene (Compound 5-3)

Preparation of 1 -chloro- 1 ,2-dihydroacenaphthylene (Compound 5-3)[00228j To a solution of Compound 5-2 (220 mg, 1.2 mmol, 1.0 eq) anddimethyl formamide (2 drops, cat) in dichloromethane (40 mL) was added sulfurous dichloride (456 mg, 2.4 mmol, 2.0 eq) dropwise at -20 °C. The mixture was stirred atthis temperature for 2 h. Upon the completion, the mixture was concentrated in vacuo below 20 °C to give 5-3 (270 mg, used directly for next step). MS (ES): mlz: 153 [M36+H] .

References:

WO2014/106238,2014,A1 Location in patent:Paragraph 00228; 00290