1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE synthesis
- Product Name:1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
- CAS Number:103816-19-9
- Molecular formula:C11H19ClN2O
- Molecular Weight:230.73
4897-50-1
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32315-10-9
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103816-19-9
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Yield: 99%
Reaction Conditions:
with triethylamine in dichloromethane at -10 - 20; for 4 h;
Steps:
5.1 Step 1) [1,4'-Bipiperidine] -1'-formyl chloride
Dissolve triphosgene (882mg, 2.97mmol) in 30mL of dichloromethane, and then dropwiseadd 1,4'-bipiperidine (500mg, 2.97mmol) and triethylamine (900mg, 8.91mmol)at -10 ° C.Dichloromethane solution (20 mL). After the dropwise addition was continued, the reaction was stirred at -10 ° C for 2 hours, and then transferredto room temperature for 2 hours.It was concentrated under reduced pressure, 20 mL of tetrahydrofuran was added to the residue, and the mother liquid was concentrated under reduced pressure to obtain the white title compound(680 mg, yield: 99%).
References:
Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Wang Xiaojun;Zhou Pingjian;Yang Chuanwen;Zhang Yingjun CN104387358, 2016, B Location in patent:Paragraph 0161-0164
4897-50-1
398 suppliers
$19.00/5g
503-38-8
123 suppliers
$15.00/5g
103816-19-9
81 suppliers
$43.00/1g