1-ETHYL-4-(4-NITROBENZYL)PIPERAZINE synthesis
- Product Name:1-ETHYL-4-(4-NITROBENZYL)PIPERAZINE
- CAS Number:414880-35-6
- Molecular formula:C13H19N3O2
- Molecular Weight:249.31
5308-25-8
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100-14-1
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$10.00/5g
414880-35-6
32 suppliers
$90.00/1g
Yield:414880-35-6 93%
Reaction Conditions:
with potassium carbonate in propan-2-one at 45;Reflux;
Steps:
Step a: Preparation of 1-ethyl-4-(4-nitrobenzyl)piperazine (M-1)
4-Nitrobenzyl chloride (7.00 g, 40.80 mmol) was dissolved in acetone (100 mL), N-ethylpiperazine (5.59 g, 48.96 mmol) and potassium carbonate (11.28 g, 81.59 mmol) were added, and the temperature was raised to 45°C The reaction was refluxed overnight. The next day, the reaction was complete by TLC monitoring.The heating and stirring were stopped, and the filtrate was obtained through diatomite-assisted filtration, and the filtrate was concentrated under reduced pressure to obtain a brown liquid.The crude product was recrystallized from ethyl acetate to give M-1 as a yellow solid (9.50 g, 93.5%).
References:
CN114751874,2022,A Location in patent:Paragraph 0073-0076
5308-25-8
462 suppliers
$15.00/5G
100-00-5
26 suppliers
$14.00/25g
414880-35-6
32 suppliers
$90.00/1g