1-ETHYLPIPERIDINE-4-CARBOXYLIC ACID synthesis
- Product Name:1-ETHYLPIPERIDINE-4-CARBOXYLIC ACID
- CAS Number:90204-94-7
- Molecular formula:C8H15NO2
- Molecular Weight:157.21
99065-42-6
6 suppliers
inquiry
90204-94-7
42 suppliers
$131.59/100mg
Yield:90204-94-7 700 mg
Reaction Conditions:
with methanol;lithium hydroxide monohydrate at 50; for 1 h;
Steps:
9.2 Step 2: Synthesis of compound 9-2
At room temperature, LiOH (447.57 mg, 18.69 mmol) was added to a MeOH (10 mL) solution of compound9-1 (1.7 g, 9.34 mmol), and the mixture was moved to 50°C reacting for 1 hour. Add the dilute hydrochloric acid solutionequivalent to LiOH to free the target product and spin to dry directly. The residue was purified by flash silica gel columnchromatography (DCM:MeOH=92:8-90:10) to obtain the desired target as a yellow solid product 9-2 (700 mg, 44.85%yield). ESI-MS m/z: 158.15 [M+H]+.
References:
EP3967695,2022,A1 Location in patent:Paragraph 0153; 0155
24252-38-8
34 suppliers
$237.00/500mg
90204-94-7
42 suppliers
$131.59/100mg
2971-79-1
285 suppliers
$10.00/10g
90204-94-7
42 suppliers
$131.59/100mg