1-(Naphthalen-2-yl)piperazine hydrochloride synthesis
1synthesis methods
- Product Name:1-(Naphthalen-2-yl)piperazine hydrochloride
- CAS Number:104090-87-1
- Molecular formula:
- Molecular Weight:0
Yield:104090-87-1 58%
Reaction Conditions:
in diethylene glycol dimethyl ether at 149;
Steps:
5.1 Step 1. Formation of 1-naphthalen-2-yl-piperazine hydrochloride
0430] A solution of naphthalen-2-amine (2 g, 14 mmol) and bis(2-chloroethyl)amine hydrochloride (2.51 g, 14.1 mmol, 1 eq) in diethylene glycol monoethyl ether (3 mL) was stirred overnight at 149° C. (oil bath). The resulting solution was diluted with methanol (2 ml). The crude product was re-crystallized from diethyl ether to afford 1-(naphthalen-2-yl)piperazine hydrochloride as a yellow solid (2 g, 58%). (ES, m/z): [M+H]+ 213.0
References:
US2014/142114,2014,A1 Location in patent:Paragraph 0429; 0430