1-Piperazineethanol,4-ethyl-(7CI,8CI,9CI) synthesis
- Product Name:1-Piperazineethanol,4-ethyl-(7CI,8CI,9CI)
- CAS Number:3221-25-8
- Molecular formula:C8H18N2O
- Molecular Weight:158.24
Yield:3221-25-8 78%
Reaction Conditions:
with potassium carbonate in acetonitrile; for 16 h;Reflux;
Steps:
2.A
Step A: Preparation of 2-(4-ethylpiperazin-l-yl)ethanol: 1 -Ethylpiperazine(5.0 g, 43.8 mmol) was dissolved in 90 mL of acetonitrile, followed by the addition of powdered potassium carbonate (18.2 g, 131 mmol), and 2-bromoethanol (10.9 g, 87.6 mmol). This mixture was warmed to reflux for 16 hours, cooled to ambient temperature, and filtered. The filtrate was concentrated under reduced pressure and purified by column chromatography (10% MeOH/DCM/0.5% NH4OH) to give 5.4 g (78%) of 2-(4-ethylpiperazin-l-yl)ethanol as a light yellow oil.
References:
WO2012/82689,2012,A1 Location in patent:Page/Page column 60
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