1-PYRIDIN-2-YL-ETHYLAMINE synthesis
- Product Name:1-PYRIDIN-2-YL-ETHYLAMINE
- CAS Number:42088-91-5
- Molecular formula:C7H10N2
- Molecular Weight:122.17
1122-62-9
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42088-91-5
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Yield: 90%
Reaction Conditions:
Stage #1:2-acetylpyridine with hydroxylamine hydrochloride;potassium carbonate in methanol at 20; for 4 h;
Stage #2: with ammonium chloride;zinc at 20;
Steps:
1.1 Step 1: Preparation of 2-(1-aminoethyl)pyridine
2-acetylpyridine (5 g, 41.2 mmol) and hydroxylamine hydrochloride (3.44 g, 49.5 mmol) were dissolved in methanol (100 mL) at room temperature, Potassium carbonate (17 g, 124 mmol) was added with stirring. The reaction mixture was stirred at room temperature for 4 hours, Filter solids, To the filtrate was added zinc powder (13.5 g, 206 mmol) and ammonium chloride (11 g, 206 mmol) in this order. The reaction mixture was stirred overnight at room temperature. Filter solids, The organic solvent was removed by steam distillation under reduced pressure. The crude product was added with an aqueous solution of sodium hydroxide, Adjust the pH ~ 13, the aqueous phase with dichloromethane extraction (50mL × 3), The combined organic phases were washed with saturated brine, Dried over anhydrous sodium sulfate and steamed to give 2- (1-aminoethyl) pyridine (4.5 g, yield 90%).
References:
Hainan Yuekang Biomedical Co., Ltd.;Zhang, Tongmei CN106279160, 2017, A Location in patent:Paragraph 0129; 0133; 0134; 0135
79462-42-3
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42088-91-5
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6959-47-3
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