1-(pyridin-4-yl)ethane-1,2-diol hydrochloride synthesis

Yield:1750-97-6 92%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane;methanol;

Steps:

A.10.2

OH OH HO t t-BuOH, 92% The title compound was prepared as provided in Tetrahedron: Asymm. 1995,6, 505-518 (Reference for Sharpless asymmetric dihydroxylation); J. Org. Chem. 1965,30, 1331-1333; 1969 U. S. Patent No. 3,464, 997 (Reference for hydrogenation

References:

WO2005/26145,2005,A2 Location in patent:Page/Page column 84; 108