1-tert-butyl-4-iodobenzene synthesis
- Product Name:1-tert-butyl-4-iodobenzene
- CAS Number:35779-04-5
- Molecular formula:C10H13I
- Molecular Weight:260.11
123324-71-0
35779-04-5
GENERAL METHOD: 4-tert-butylphenylboronic acid (0.067 g, 0.4 mmol), copper powder (0.0052 g, 0.08 mmol), (CF3)2CFI (0.178 g, 0.6 mmol), and DMF (2 mL) were added to a hermetically sealed reaction tube with a rubber stopper. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the resulting suspension was poured into water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous Na2SO4 and subsequently concentrated to dryness under reduced pressure. The crude product was purified by silica gel fast column chromatography using petroleum ether/ethyl acetate (20:1, v/v) as eluent to afford 1-tert-butyl-4-iodobenzene (0.086 g, 0.35 mmol, 87% yield) as a light yellow solid.
123324-71-0
408 suppliers
$5.00/1g
35779-04-5
204 suppliers
$6.00/1g