Benzoic acid, 4-(1-isocyanatocyclopropyl)-, Methyl ester synthesis
- Product Name:Benzoic acid, 4-(1-isocyanatocyclopropyl)-, Methyl ester
- CAS Number:1006037-10-0
- Molecular formula:C12H11NO3
- Molecular Weight:217.22
1006037-03-1
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Yield:1006037-10-0 0.69 g
Reaction Conditions:
with triethylamine in toluene at 0 - 20; for 1.5 h;
Steps:
1.1 Step 1: Methyl 4-(l-isocyanatocyclopropyl)benzoate
To a solution of methyl 4-(l-aminocyclopropyl)benzoate (1.3 g, 6.87 mmol) and triphosgene (0.621g, 2.09 mmol) in toluene (30 mL) was added Et3N (1.45 mL, 10.46 mmol) dropwise at 0 °C. This reaction was stirred at 0 °C for 30 min Then, stirred at room temperature for lh. TLC check reaction, the starting material was consumed by TLC, and filtration this suspension and concentration to give a 0.69 g of the title product as a pale-yellow solid, which was used for next step without further purification.
References:
WO2019/152982,2019,A1 Location in patent:Paragraph 082
