3-(TRIFLUOROMETHYL)-7,8,9,10-TETRAHYDRO-5H-PYRIDO[1,2-A]QUINOXALIN-6(6AH)-ONE synthesis
1synthesis methods
- Product Name:3-(TRIFLUOROMETHYL)-7,8,9,10-TETRAHYDRO-5H-PYRIDO[1,2-A]QUINOXALIN-6(6AH)-ONE
- CAS Number:1009240-54-3
- Molecular formula:C13H13F3N2O
- Molecular Weight:270.25
Yield:1009240-54-3 70%
Reaction Conditions:
Stage #1: N-[2-bromo-5-(trifluoromethyl)phenyl]-2,2,2-trifluoroacetamide;pipecolic Acidwith copper(l) iodide;caesium carbonate in dimethyl sulfoxide at 110;Inert atmosphere;
Stage #2: with water in dimethyl sulfoxide at 100;Inert atmosphere;
References:
Xu, Lanting;Jiang, Yongwen;Ma, Dawei [Synlett,2010,# 15,p. 2285 - 2288] Location in patent:supporting information; experimental part