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ChemicalBook CAS DataBase List (2R,4R)-4-Hydroxy-2-pyrrolidineMethanol Hydrochloride

(2R,4R)-4-Hydroxy-2-pyrrolidineMethanol Hydrochloride synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: diborane / tetrahydrofuran / 2 h / 65 °C
2: hydrogen; 20% palladium hydroxide-activated charcoal / ethanol / 760.05 Torr

References:

Gustin, Darin J.;Li, Yihong;Brown, Matthew L.;Min, Xiaoshan;Schmitt, Mike J.;Wanska, Malgorzata;Wang, Xiaodong;Connors, Richard;Johnstone, Sheere;Cardozo, Mario;Cheng, Alan C.;Jeffries, Shawn;Franks, Brendon;Li, Shyun;Shen, Shanling;Wong, Mariwil;Wesche, Holger;Xu, Guifen;Carlson, Timothy J.;Plant, Matthew;Morgenstern, Kurt;Rex, Karen;Schmitt, Joanna;Coxon, Angela;Walker, Nigel;Kayser, Frank;Wang, Zhulun [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 16,p. 4608 - 4616]

343633-22-7 Synthesis
(2R,4R)-4-Hydroxy-2-pyrrolidinemethanol

343633-22-7
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