Ethyl 7 - ((7 - Methoxy - 4 - oxo - 3,4 - dihydroquinazolin - 6 - yl)oxy)heptanoate synthesis
- Product Name:Ethyl 7 - ((7 - Methoxy - 4 - oxo - 3,4 - dihydroquinazolin - 6 - yl)oxy)heptanoate
- CAS Number:1012057-25-8
- Molecular formula:C18H24N2O5
- Molecular Weight:348.39
1012067-93-4
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Yield:1012057-25-8 99%
Reaction Conditions:
with ammonium formate at 180; for 3 h;
Steps:
8.8e
A mixture of compound 0405-12 (8.71 g, 23.7 mmol), ammonium formate(1.48 g, 23.7 mmol) and formamide (40 mL) was stirred at 180 0C for 3 hours. After reaction the mixture was cooled to room temperature. The formamide was removed under reduce pressure, and the residue was dissolved in dichloromethane and washed with brine. The organic phase was dried over sodium sulfate, filtered and concentrated to give the title product 0406-12 as a pale white solid (8.18g, 99%):LCMS: 349 [M+ 1]+, 1H NMR (DMSO-J6): Jl.17 (t, J= 6.9 Hz, 3H), 1.38 (m, 4H),1.55 (m, 2H), 1.75 (m, 2H), 2.29 (t, J= 7.2 Hz, 2H), 3.90 (s, 3H), 4.05 (m, 4H), 7.13(s, IH), 7.42 (s, IH), 7.97 (d, J= 3.6 Hz, IH), 12.07 (s, IH).
References:
WO2008/33747,2008,A2 Location in patent:Page/Page column 116
1012057-22-5
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29823-18-5
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3943-89-3
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