5-Methyl-benzo[b]thiophene-2-carboxylic acid ethyl ester synthesis
2synthesis methods
- Product Name:5-Methyl-benzo[b]thiophene-2-carboxylic acid ethyl ester
- CAS Number:101219-39-0
- Molecular formula:C12H12O2S
- Molecular Weight:220.29
Yield:101219-39-0 74%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80; for 4 h;
Steps:
8B
A mixture of 2-fluoro-5-methylbenzaldehyde (2.0 g, 14 mmol), ethyl 2-mercaptoacetate (1.8 g, 17 mmol) and potassium carbonate (4.0 g, 29 mmol) in N, N-dimethylformamide (30 mL) was stirred at 80 °C for 4 hours. On completion, the mixture was poured into ice-water, resulting in formation of a solid. The mixture was stirred for 30 min., and the solid was collected by filtration, washed with water and dried in vacuo to give compound B-108 (2.2 g, 74% yield) as a yellow solid.
References:
WO2016/100184,2016,A1 Location in patent:Paragraph 00282
