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4-[(5Z)-5-BENZYLIDENE-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL]BENZOIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydroxide / water / 16 h / 20 °C
1.2: 3 h / 20 °C
1.3: 16 h / Reflux
2.1: acetic acid; ammonium acetate / 4 h / 120 °C

References:

Xiang, Yang;Chen, Cheng;Wang, Wen-Ming;Xu, Li-Wei;Yang, Ke-Wu;Oelschlaeger, Peter;He, Yuan [ACS Medicinal Chemistry Letters,2018,vol. 9,# 4,p. 359 - 364]