2-(2,5-dichloropyrimidin-4-ylamino)-N,N-dimethylbenzenesulfonamide synthesis
- Product Name:2-(2,5-dichloropyrimidin-4-ylamino)-N,N-dimethylbenzenesulfonamide
- CAS Number:1022956-26-8
- Molecular formula:C12H12Cl2N4O2S
- Molecular Weight:347.22
54468-86-9
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$14.00/100mg
5750-76-5
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Yield:1022956-26-8 64%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine for 12 h;Reflux;
Steps:
4.1.1.12. (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide (51l).
General procedure: A solution of 2,4,5-trichloropyrimidine(1.82 g, 10 mmol), (2-aminophenyl)dimethylphosphine oxide(1.69 g, 10 mmol) and N,N-diisopropylethylamine (1.94 g, 15 mmol)in propan-2-ol (25 mL) was heated under reflux for 12 h. The solvent was removed by evaporation and the residue was dissolvedin CH2Cl2 (100 mL). The solution was washed with water andsaturated sodium chloride solution and dried, filtered andconcentrated. The residuewas purified by flash chromatography onsilica gel (0e2% MeOH in DCM) to afford compound 51l (1.60 g,50%).
References:
Chen, Yongfei;Wu, Jiaxin;Wang, Aoli;Qi, Ziping;Jiang, Taoshan;Chen, Cheng;Zou, Fengming;Hu, Chen;Wang, Wei;Wu, Hong;Hu, Zhenquan;Wang, Wenchao;Wang, Beilei;Wang, Li;Ren, Tao;Zhang, Shanchun;Liu, Qingsong;Liu, Jing [European Journal of Medicinal Chemistry,2017,vol. 139,p. 674 - 697]
1694-92-4
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1022956-26-8
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23530-43-0
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1022956-26-8
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