2-(2-[4-(3-BENZYLOXY-PHENYLSULFANYL)-2-CHLORO-PHENYL]-ETHYL)-2-FLUORO-MALONIC ACID DIETHYL ESTER synthesis
1synthesis methods
- Product Name:2-(2-[4-(3-BENZYLOXY-PHENYLSULFANYL)-2-CHLORO-PHENYL]-ETHYL)-2-FLUORO-MALONIC ACID DIETHYL ESTER
- CAS Number:1023648-24-9
- Molecular formula:C28H28ClFO5S
- Molecular Weight:531.04
![1-[(3-Chloro-4-ethenylphenyl)thio]-3-(phenylmethoxy)benzene](/CAS/20200515/GIF/1023648-20-5.gif)
Yield:1023648-24-9 55%
Reaction Conditions:
Stage #1: fluoromalonic acid diethyl esterwith caesium carbonate in dimethyl sulfoxide at 20; for 0.5 h;
Stage #2: 3-[3-(benzyloxy)phenylthio]-6-vinyl-1-chlorobenzene in dimethyl sulfoxide at 20 - 35;Further stages.;
References:
Chino, Masao;Kiuchi, Masatoshi;Adachi, Kunitomo [Tetrahedron,2008,vol. 64,# 17,p. 3859 - 3866]