2-(diethylamino)-N-(2,4,6-trimethylphenyl)acetamide monohydrochloride synthesis
- Product Name:2-(diethylamino)-N-(2,4,6-trimethylphenyl)acetamide monohydrochloride
- CAS Number:1027-14-1
- Molecular formula:C15H25ClN2O
- Molecular Weight:284.8248
1152-39-2
43 suppliers
$65.00/500mg
109-89-7
449 suppliers
$10.00/5g
1027-14-1
111 suppliers
$172.00/25MG
Yield:1027-14-1 90.9%
Reaction Conditions:
in n-heptane at 50; for 7 h;Reflux;Large scale;Solvent;
Steps:
1.2; 2.2; 3.2 Preparation of trimecaine hydrochloride:
912 kg n-heptane, diethylamine 131kg into the 2000L reactor, with stirring was added the above intermediate.Heating to reflux for 7 hours, cooled to 50 deg.] C was added water, washed once 400kg, 200kg water, washed once coupled, and finally dried with sodium sulphate.The material was filtered into another reaction vessel, heated up concentrated under reduced pressure and dissolved with stirring distilled addition of n-heptane, cool, add methanol 152kg.Hydrochloric acid with 82kg dimming control at pH 1-2, it done acid methanol was distilled off under reduced pressure, added with acetone dispersion 152kg crystallization.Cooled to below 0 Crystallization two hours rejection materials, drying wet product was obtained in three tetracaine hydrochloride 191.5kg, total yield 90.9%, purity 99.92% liquid.
References:
CN109456218,2019,A Location in patent:Paragraph 0022-0024
88-05-1
312 suppliers
$6.00/1g
1027-14-1
111 suppliers
$172.00/25MG