4,4,5,5-tetramethyl-2-(4-((3-methylbenzyl)oxy)phenyl)-1,3,2-dioxaborolane synthesis
- Product Name:4,4,5,5-tetramethyl-2-(4-((3-methylbenzyl)oxy)phenyl)-1,3,2-dioxaborolane
- CAS Number:1029439-14-2
- Molecular formula:C20H25BO3
- Molecular Weight:324.22
620-13-3
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Yield:-
Reaction Conditions:
with cesium fluoride in acetonitrile at 20; for 20 h;
Steps:
81
A tube was charged with phenol 63 (100 mg, 1 eq), CsF on Celite (180 mg, 60% by weight, 1.5 eq), acetonitrile (6 mL). To this tube 3-methylbenzyl bromide 128 (168 mg, 2 eq) was added. The reaction was stirred at rt for 20 h. TLC showed desired product. The reaction mixture was filtered, concentrated. The residue was purified by flash chromatography (5% EtOAc in hexanes then 10% EtOAc) to afford 80 mg of desired product 129.
References:
WO2008/63300,2008,A2 Location in patent:Page/Page column 200